Publications by authors named "G de Roberto"
Article Synopsis
- - Collective cell migration is important for processes like development, healing, and cancer spread, and in the study of Drosophila, border cells (BCs) migrate with the help of a kinase called Misshapen (Msn).
- - The protein Tao serves as an important activator of Msn in border cells; reducing Tao levels hinders BC migration, mimicking the effects of a loss of Msn function.
- - Msn's distribution is influenced by its interaction with a protein called Rap2l, which assists in transporting Msn to the endolysosomal pathway for degradation; this process is critical for maintaining balanced Msn levels and activity in BCs.
Few studies have been published on the long-term outcomes of patients with gastric neuroendocrine tumors (gNETs). We analyzed their management over a two-decade period, focusing on endoscopic and clinical outcomes. Clinical, laboratory, endoscopic, surgical, and histopathological data from Types 1 and 3 gNETs histologically diagnosed between March 2000 and December 2021 at the European Institute of Oncology (IEO, Milan) were retrospectively collected.
View Article and Find Full Text PDFPurpose: Metadata for data dIscoverability aNd study rEplicability in obseRVAtional studies (MINERVA), a European Medicines Agency-funded project (EUPAS39322), defined a set of metadata to describe real-world data sources (RWDSs) and piloted metadata collection in a prototype catalogue to assist investigators from data source discoverability through study conduct.
Methods: A list of metadata was created from a review of existing metadata catalogues and recommendations, structured interviews, a stakeholder survey, and a technical workshop. The prototype was designed to comply with the FAIR principles (findable, accessible, interoperable, reusable), using MOLGENIS software.
Background: Cushing's syndrome due to ectopic ACTH secretion is a rare clinical condition resulting from a dysregulated ACTH secretion by neuroendocrine tumors. The overall incidence of endogenous Cushing's syndrome is 0.7-2.
View Article and Find Full Text PDF