Publications by authors named "G de Maria"
Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection.
Front Cell Neurosci
January 2025
Background: Following transection, nerve repair using the polylactic acid (PLA) conduit is an effective option. In addition, inosine treatment has shown potential to promote nerve regeneration. Therefore, this study aimed to investigate the regenerative potential of inosine after nerve transection and polylactic acid conduit repair.
View Article and Find Full Text PDFBackground & Aims: Noninvasive tests (NITs) for ruling-out clinical significant portal hypertension (CSPH) and high-risk varices (HRVs) in patients with primary biliary cholangitis (PBC) and compensated advanced chronic liver disease (cACLD) are lacking. We evaluated NITs in these patients and the influence of cholestasis on their performance.
Methods: Consecutive patients from the "Italian PBC registry" and 2 United Kingdom large-volume PBC referral centers with upper endoscopy within 6 months from biochemical evaluation and transient elastography were included.
Comparison of a Fully Angiography-Derived Versus a Hybrid of Angiography and Pressure-Wire-Derived Approach to Assess Coronary Microvascular Resistance: The Oxford Acute Myocardial Infarction Hybrid (OxAMI-HYBRID) Study.
Catheter Cardiovasc Interv
January 2025
Article Synopsis
- The study explores the assessment of coronary microvascular dysfunction (CMD) using a new hybrid index derived from pressure-wire measurements and angiography, promoting its potential use in clinical settings.
- Researchers compared this hybrid index, known as IMR, with a traditional bolus thermodilution-based index in a cohort of patients with acute coronary syndrome and stable coronary artery disease.
- Results indicate that both the new hybrid IMR and the traditional index showed strong correlations and diagnostic accuracy for CMD, suggesting IMR is a simpler and effective alternative for routine clinical use.
Article Synopsis
- This study examines how early clinical hepatic decompensation (CHD) affects the overall survival (OS) of patients with unresectable hepatocellular carcinoma (uHCC) who are receiving systemic treatments like Atezolizumab plus Bevacizumab or Sorafenib.
- Researchers analyzed data from the IMbrave150 trial and found that patients experiencing early CHD had a significantly higher risk of mortality, indicating a poor prognosis.
- The study identifies specific factors (like ALBI grade, INR levels, and macrovascular invasion) that put patients at a greater risk for CHD, suggesting that these could be useful in future clinical trials to better assess patient outcomes.
Spinal cord injury (SCI) is one of the most serious conditions of the central nervous system, causing motor and sensory deficits that lead to a significant impairment in the quality of life. Previous studies have indicated that inosine can promote regeneration after SCI. Here we investigated the effects of inosine on the behavioral and morphological recovery after a compressive injury.
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