Long-term melatonin treatment prolongs interestrus, but does not delay puberty, in domestic cats.

The objective was to assess the efficacy and safety of long-term administration of melatonin (either as an implant or given orally) on interestrus intervals in domestic cats. Additionally, the effect of melatonin implants on puberty postponement was studied. For these purposes, two randomized controlled trials were conducted.

Epithelioid hemangioendothelioma of the central nervous system. Immunohistochemical and ultrastructural observations of a pediatric case.

In 1982, Weiss and Enzinger described a group of soft tissue tumors in adults that they called epithelioid hemangioendothelioma [Cancer 50: 970-981, 1982]. Such tumors have also been found in heart, bone, liver, lung and lymph nodes, and Kepes and Rubinstein described two intracranial examples in adults in 1986 [J. Neuropath.