Intrapelvic acetabulum surgery: does the positioning of the plate fixation play a role in the stability of the osteosynthesis?

Objectives: This study aims to investigate whether positioning of the plate fixation plays a role in the stability of the osteosynthesis.

Materials And Methods: We used finite element modelling to model an anterior pillar fracture and a T-type fracture of the acetabulum. Fracture fixation was carried out in three different variations: cranially positioned plate, medially positioned plate, and a combination of the two methods.

[Development of PAK1 kinase inhibitors with "in silico" modeling methods].

The important role of several protein kinases in many diseases has been well documented. Nowadays they are known as an important class of drug targets. The similarity of the structures of the protein kinases makes the development of selective inhibitors difficult.