[Acquired melanocytic nevus. Epidemiologic clinical study of a healthy population].

Total body naevi counts have been performed on 3931 Italian subjects aged 5 to 79 years (2063 males and 1868 females). Only naevi greater than or equal to 2 mm in diameter were recorded. The total mean naevi count was 15 (15 for males, 14 for females); in the first decade of life the count was 8, rising rapidly in the second decade to a mean of 18 and was 22 in the third decade.

[Azelaic acid in the treatment of acne].

This review is an update of the literature accumulated over the past 6 years following the original observation that topically applied azelaic acid, a non-toxic C9 dicarboxylic acid, has a beneficial therapeutic effect on acne vulgaris. These studies have shown that azelaic acid has a modulating influence on the process of keratinization, and that it acts as a keratolytic and anti-comedogenic agent. There is evidence that it inhibits mitochondrial and microsomal oxido-reductases, including 5-alpha-reductase, and that it may interfere with the process of sebogenesis.