The influence of product aesthetics and usability over the course of time: a longitudinal field experiment.

Unlabelled: A longitudinal field experiment was carried out over a period of 2 weeks to examine the influence of product aesthetics and inherent product usability. A 2 × 2 × 3 mixed design was used in the study, with product aesthetics (high/low) and usability (high/low) being manipulated as between-subjects variables and exposure time as a repeated-measures variable (three levels). A sample of 60 mobile phone users was tested during a multiple-session usability test.

Effects of interferons and hydrogen peroxide on CA3 pyramidal cells in rat hippocampal slice cultures.

In viral diseases of the CNS, both interferon-alpha/beta and interferon-gamma are produced intrathecally. At least some of the neurological symptoms associated with these diseases may be due to the effects of these cytokines. We have studied the actions of interferons on CA3 pyramidal cells in hippocampal slice cultures.

The concept of multispecies testing in industrial toxicology.

The multispecies approach in toxicity testing was originally motivated by the frequent findings of species differences in responsiveness to the pharmacological and acute toxic effects of chemicals. When the guidelines for repeated-dose toxicity experiments were developed in the early 1940s, the concept of using several species of animals was automatically included without careful scientific validation. In response to demands from the U.

Neurotoxic effects of bismuth in vitro.

Although insoluble bismuth (Bi) salts are known to be neurotoxic, recently interest in oral Bi therapy has been renewed because of encouraging results obtained in the treatment of gastritis and peptic ulcer associated with Helicobacter pylori infection. For risk assessment of orally administered Bi preparations it is important to determine the minimal neurotoxic Bi concentration in the brain. This concentration was determined in cultures of brain, meninges and neuronal retina cells from embryonic chicks and in cultures of hippocampal slices from rats.