Effect of antacids in didanosine tablet on bioavailability of isoniazid.

The antacids in two didanosine placebo tablets had no significant effect on the plasma pharmacokinetics of a single oral dose of 300 mg of isoniazid administered to 12 healthy volunteers. These results suggest that isoniazid bioavailability will be unaffected by the antacids in didanosine tablets when the two medications are administered simultaneously to human immunodeficiency virus-seropositive patients.

Vitamin E levels in gastric mucosa and indomethacin-induced gastric lesions in rats.

The role of vitamin E as a gastroprotective agent from indomethacin-induced damage was investigated in male rats with deficient or supplemented levels of vitamin E in their blood and tissues. Ten weeks of feeding a vitamin E deficient diet produced very low levels of the vitamin in all the tissues studied (below 1.2 micrograms/g tissue).

Repletion and depletion of vitamin E in gastroduodenal mucosa.

Male rats were used to assess the effect of fasting and depletion and repletion rates on the levels of vitamin E in the liver and in mucosa from the fundus, antrum, and duodenum. Fasting for 24 h did not produce a significant decrease in vitamin E content in gastroduodenal mucosa. Feeding rats a diet low in vitamin E content for 10 weeks produced very low levels of the vitamin in all the tissues studied (below 2.

Lack of vitamin E cytoprotective effects on indomethacin-induced gastric lesions.

The ability of vitamin E to protect the gastric mucosa from the ulcerogenic effect of indomethacin was assessed in male rats. A single administration of vitamin E to rats increased levels of vitamin E in fundus (80%), antrum (130%), duodenum (450%), liver (450%), and plasma (230%) in comparison to vehicle treated rats. Oral administration of 30 mg/kg indomethacin to rats previously treated with vitamin E (100 mg/kg), vitamin E-stripped corn oil (vehicle), or to sham pretreated rats induced similar cumulative length and score of gastric lesions in the three groups of animals.

Capsaicin desensitization induces atrophy of brown adipose tissue in rats.

Interscapular brown adipose tissue (BAT) of capsaicin-desensitized (Cap-Des) rats is atrophied, having a lower wet weight, a reduced total protein content, and as little as 10% of the normal content of uncoupling protein (UCP). Because the mitochondrial concentration of UCP, relative to other mitochondrial proteins, is not altered in Cap-Des rats, it is concluded that most of the mitochondria of BAT of Cap-Des rats have been lost. Consistent with this interpretation is a reduction of almost 40% of the overall thermogenic response to infused norepinephrine by anesthetized Cap-Des rats.