Effect of sodium valproate on the spontaneous contractile and bioelectric activity of smooth muscle fibres isolated from experimental animals.

Experiments were carried out with smooth muscles preparations of 24 rats (gastric corpus) and 36 guinea pigs (gastric corpus and taenia coli). Their contractile responses were recorded isometrically using tensile transducers. The bioelectric activity was determined by the single sucrose-gap method.

[A pharmacological analysis of the mechanism of action of ethosuximide].

Ethosuximide is one of the means of treatment of minor epilepsy but hardly any data on its mechanism of action are available in the literature. Anticonvulsant agents are known to bring about changes in the functions and in the interaction between some of the mediator systems within the central nervous system. An assessment of the status of neuromediator systems can be made on the basis of the response of isolated smooth muscle strips to the action of agonists and antagonists of various receptors.