Blockade of bradykinin receptors or angiotensin II type 2 receptor prevents paclitaxel-associated acute pain syndrome in mice.

Background: Paclitaxel (PCX) is the first-line choice for the treatment of several types of cancer, including breast, ovarian, and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical and cold allodynia, a symptom known as PCX-associated acute pain syndrome (P-APS). Here, we assessed possible involvement of kinin-kallikrein and renin-angiotensin systems in P-APS in mice.

Short-term blood pressure variability outweighs average 24-h blood pressure in the prediction of cardiovascular events in hypertension of the young.

Objective: The association of short-term blood pressure (BP) variability (BPV) with cardiovascular events (CVEs) is controversial. Aim of this study was to investigate whether BPV measured as weighted 24-h SD was associated with CVE in a prospective cohort study of young patients screened for stage 1 hypertension.

Methods: We performed 24-h ambulatory BP monitoring in 1206 participants aged 33.

Factors associated with glomerular hyperfiltration in the early stage of hypertension.

Background: Glomerular hyperfiltration predicts development of nephropathy in hypertension but the factors responsible for increased glomerular filtration rate (GFR) are not well known. Aim of this study was to examine which clinical variables influence GFR in the early stage of hypertension.

Methods: Participants were 1,106 young-to-middle-age hypertensive adults with creatinine clearance >60 ml/min/1.

Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity.

Background And Aims: The G-protein regulator phosducin has been shown to be associated with stress-dependent blood pressure, but whether obesity is a modulator of the relationship between phosducin and risk of hypertension is unknown. We studied the effect of two phosducin polymorphisms on risk of hypertension in 273 overweight or obese (Ov-Ob) young-to-middle-age participants from the HARVEST and 287 normal weight (NW) participants.

Methods And Results: Genotyping of phosducin SNPs rs12402521 and rs6672836 was performed by real time PCR.

Cystatin C as predictor of microalbuminuria in the early stage of hypertension.

Background/aims: Predictors of microalbuminuria in the early stage of hypertension are not well known. We did a prospective study to investigate whether glomerular hyperfiltration assessed from serum cystatin C predicts development of microalbuminuria in hypertension.

Methods: We assessed 101 treatment-naive subjects screened for stage 1 hypertension and followed-up for a median 3.