Publications by authors named "G Zai"
Background: The World Health Organization has recognized maternal mental illness as an emerging issue. Previous studies have indicated that maternal mental illness is associated with socioeconomic status (SES). However, there is a lack of research concerning the mental health of pregnant people with low SES in Ontario, Canada.
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- Major depressive disorder (MDD) affects about 250 million people globally, highlighting the need for effective treatment strategies that consider factors like chronotype (individual preference for morning or evening activities) and the timing of therapy sessions.
- A study involving 227 outpatients diagnosed with MDD examined how their chronotype and the time of day they received cognitive behavioral therapy influenced their post-treatment depression severity.
- Findings showed increases in morningness for those in the afternoon and evening therapy groups, with a significant connection between changes in morningness and depression severity for the afternoon group, although the lack of a control group limits the study's conclusions.
Article Synopsis
- * A genome-wide association meta-analysis of nearly 122,000 ANX cases revealed 58 significant genetic variants and 66 related genes, with many of these findings replicated in a larger independent sample.
- * The findings indicate a substantial genetic overlap between ANX and other conditions like depression, emphasizing GABAergic signaling as a key mechanism, thereby enhancing our understanding of the genetic basis of ANX for future research.
Research demonstrates the important role of genetic factors in attention-deficit/hyperactivity disorder (ADHD). DNA sequencing of families provides a powerful approach for identifying de novo (spontaneous) variants, leading to the discovery of hundreds of clinically informative risk genes for other childhood neurodevelopmental disorders. This approach has yet to be extensively leveraged in ADHD.
View Article and Find Full Text PDFGiven that anxiety disorders (AD) are associated with reduced vagally-mediated heart rate variability (HRV), genetic variants related to HRV may provide insight into anxiety etiology. This study used polygenic risk scores (PRS) to explore the genetic overlap between AD and HRV, and investigated whether HRV-related polymorphisms influence anxiety risk. Resting vagally-mediated HRV was measured using a wearable device in 188 European individuals (AD=101, healthy controls=87).
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