Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.

Background: The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.

Methods: Patients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.

Efficient construction of core/double-shelled structured AP@nano-graphite@F energetic microcapsules with low sensitivity and hygroscopicity.

Ammonium perchlorate (AP) is widely utilized in aerospace, defense and other fields due to its high energy density, exceptional stability, easy availability and adaptability. However, the high sensitivity and hygroscopicity of AP severely constrain its application in numerous fields. In this study, a two-step continuous coating method was employed to construct AP-based energetic microcapsules with low sensitivity and hygroscopicity.

Preparation and Characterization of TKX-50/AP Cocrystals.

In order to achieve new energetic materials with high energy, low sensitivity, and moisture-proof properties, dihydroxylammonium 5,5'-bistetrazole-1,1'-diolate (TKX-50)/ammonium perchlorate (AP) cocrystal (molar ratio 1:1) was successfully prepared through a spray-assisted solvent-nonsolvent method. SEM shows that the morphology of the cocrystal is different from those of the two raw materials. XRD and FT-IR spectra indicate the formation of the cocrystal.

From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker.

Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites.

Xylem Hydraulics of Two Temperate Tree Species with Contrasting Growth Rates.

Hydraulic functionality is crucial for tree productivity and stress tolerance. According to the theory of the fast-slow economics spectrum, the adaptive strategies of different tree species diverge along a spectrum defined by coordination and trade-offs of a suite of functional traits. The fast- and slow-growing species are expected to differ in hydraulic efficiency and safety; however, there is still a lack of investigation on the mechanistic association between tree growth rate and tree hydraulic functionality.