THE FEATURES OF THE NORMAL ULTRASTRUCTURE OF THE RAT DUODENUM AND UNDER THE COMBINED EFFECT OF THE FOOD ADDITIVES COMPLEX.

Objective: The aim: Investigation of ultrastructural changes in the elements of rats' duodenal mucosa in norm and exposed to a complex of food additives (monosodium glutamate, sodium nitrite and Ponceau 4R).

Patients And Methods: Materials and methods: 70 rats of the experimental groups was administered 0.6 mg/kg of sodium nitrite, monosodium glutamate at a dose of 20 mg/kg, Ponceau 4R at a dose of 5 mg/kg in 0.

MONOSODIUM GLUTAMATE (E621) AND ITS EFFECT ON THE GASTROINTESTINAL ORGANS (REVIEW).

The study of the mechanisms of the effect of various food additives on the human and animal organism is one of the most pressing problems today. The work of physicians, toxicologists, physiologists is aimed at studying the mechanisms of the toxic effect of food additives, as well as studying compensatory-adaptive reactions in response to their ingestion. Monosodium glutamate (E621) is widely used in marketing as a flavor enhancer and is added to many processed foods.

REMODELING OF THE RAT DUODENAL WALL UNDER THE EFFECT OF COMPLEX FOOD ADDITIVES OF MONOSODIUM GLUTAMATE, SODIUM NITRITE AND PONCEAU 4R.

The purpose of the study was to establish the dynamics of changes in morphometric parameters of the structural components of the rats' duodenal wall with long-term use of a complex of food additives: sodium nitrite, sodium glutamate and Ponceau 4R. The work was performed on 84 adult nonlinear male rats, which were given to drink 10% sodium nitrite solution, sodium glutamate was administered at a dose of 20 mg/kg in 0.5 ml of distilled water, Ponceau 4R - at a dose of 5 mg/kg in 0.

Structural reorganization of the rats' submandibular glands acini after the influence of 1% methacrylate.

Objective: Introduction: Polymeric substances, which are used in medicine, can lead to the development of pathological conditions. Therefore, in toxicological evaluation of polymeric materials for medical purposes the primary task is the creation of the appropriate adequate methods of study. The aim: To studytheacinioftherats'submandibularsalivaryglandsin normalcondition andafter exposureof 1% methacrylate.

Remodeling of the duct system of the rat submandibular salivary glands in chronic ethanol intoxication.

Objective: The aim: To determine the dynamics of changes in metric parameters of the duct system of rat submandibular glands in normal conditions and chronic ethanol intoxication.

Patients And Methods: Materials and methods: 50 albino outbred rats were involved in the experiment. 10 animals were assigned in the control group, 40 animals - in the experimental group.