Epstein-Barr virus, vitamin D and the immune response: connections with consequences for multiple sclerosis.

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with no definitive trigger. However, epidemiological studies indicate that environmental factors, such as infection with Epstein-Barr virus (EBV) and low vitamin D (Vit D) levels in genetically predisposed individuals, are important risk factors. One leading proposal is that EBV triggers MS via mechanisms such as molecular mimicry, where activated autoreactive B and T lymphocytes mistakenly target self-antigens.

Quality of Non-Profit Hospice Affiliated with Integrated Healthcare Systems.

Context: Research shows hospice primary caregivers report better quality of care at Non-Profit (NP) than For-Profit (FP) hospices, but there is variation in quality across NP hospices.

Objective: Examine bereaved caregiver reports of the quality as a factor of whether NP hospices are part of an integrated healthcare system that included an acute care hospital.

Methods: Cross-sectional study of NP Hospices used star ratings and adjusted hospice composite quality scores May 2023 publicly data reported on the Care Compare website.

Recent Updates on Alzheimer's Disease: Pathogenesis, Pathophysiology, Molecular Approaches and Natural Bioactive Compounds Used in Contemporary Time to Alleviate Disease.

Alzheimer's disease (AD), characterised by gradual memory loss and neurodegeneration, is an important risk to global health. Despite the recent advances in the field of neuroscience, the complex biological mechanisms underlying the aetiology and pathology of AD have not been elucidated yet. The development of amyloid-beta plaques, hyperphosphorylation of tau protein, oxidative stress, and neuroinflammation have been identified as important components.

Bioremediation of polyaromatic hydrocarbon polluted sewage sludge soil employing a bacterial consortium and phytotoxicity evaluation.

A consortium of five distinct bacterial strains was evaluated for their ability to biodegrade multiple polyaromatic hydrocarbons (PAHs) in sewage sludge under microcosm studies. The presence of PAHs was determined from the sludge samples collected during pre- and post-monsoon seasons from three different wastewater treatment plants (WWTPs). Among the 16 PAHs found, the lowest concentration detected was 1.

Synthesis and evaluation of drug-loaded silver nanoparticles as hemostatic agents to halt uncontrolled bleeding.

Objective: The aim of this research study was to formulate a cost-effective, stable, less toxic and more efficacious intravenous nanoformulation that could rapidly augment the process of hemostasis.

Significance: Silver nanoparticles (AgNPs) evoked platelet activation, whereas alum (AM) neutralized the plasma proteins, causing blood coagulation. Tranexamic acid (TA) inhibited fibrinolysis and stabilized the formed blood clot.