Publications by authors named "G Y Lim"
Objective: This large cohort study aimed to examine the overall associations of physical activity (PA) and estimated cardiorespiratory fitness (eCRF) with incident chronic kidney disease (CKD).
Methods: This study included a total of 274,292 participants (mean age, 37.9±8.
Life space restriction following disruptive life events: Evidence from the COVID-19 pandemic.
J Gerontol B Psychol Sci Soc Sci
January 2025
Objectives: Restriction of life space mobility is associated with adverse health outcomes including depression, morbidity, mortality and poorer quality of life. In this study, we aimed to determine the impact of COVID-19 and associated employment loss on the life space of older adults in Singapore.
Methods: An in-person survey was administered to a cohort of older Singaporeans above 50 years old (N = 1,118).
Article Synopsis
- The introduction describes the growing issue of postoperative complications and how a new risk stratification tool, CARES-ML, aims to reduce these risks by identifying high-risk patients early.
- The study design involves a randomized controlled trial with over 9,200 patients undergoing elective surgeries, comparing outcomes between those guided by the CARES tool and those who are not.
- The ethics section ensures patient consent and language support, with the study approved by the relevant review board and funding from Singapore’s National Medical Research Council, leading to findings that will be shared in peer-reviewed journals.
Disrupting the interaction between matrix metalloproteinase-7 (MMP-7) and syndecan-2 (SDC-2) can yield anticancer effects in colon cancer cells. Here, a single-chain variable fragment (scFv) targeting the pro-domain of MMP-7 was generated as a potential candidate anticancer agent. Among the generated scFvs, those designated 1B7 and 1C3 showed the strongest abilities to inhibit the ability of MMP-7 pro-domain to directly interact with SDC-2 in vitro and decrease the cancer activities of human HT29 colon adenocarcinoma cells.
View Article and Find Full Text PDFRecent advancements in fluorescence-based biosensor technologies have enabled more precise and accurate Förster Resonance Energy Transfer (FRET) imaging within Agrobacterium-mediated plant transformation systems. However, the application of FRET imaging in plant tissues remains hindered by significant challenges, particularly the time-intensive process of generating transgenic lines and the complications arising from tissue autofluorescence. In contrast, protoplast-based FRET imaging offers a rapid and efficient platform for functional screening and analysis, making it an essential tool for plant research.
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