Publications by authors named "G Y Laflamme"
Background: Red blood cell transfusion is an effective treatment for patients with sickle cell disease (SCD). Alloimmunization can occur after a single transfusion, limiting further usage of blood transfusion. It is recommended to match for the ABO, D, C, E, and K antigens to reduce risks of alloimmunization.
View Article and Find Full Text PDFObjective: Hormonal therapy is a standard treatment for children with infantile spasms. However, the high doses given and long treatment duration expose patients to the risk of adrenal insufficiency (AI). This study aims to quantify the cumulative incidence of AI among children with infantile spasms treated with high-dose corticosteroids and/or adrenocorticotropic hormone.
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- This study explores the effectiveness of direct visualization (DV) versus fluoroscopy in evaluating syndesmosis instability in the ankle, proposing that DV may be more accurate.
- Ten cadaveric ankles underwent a series of tests to model syndesmosis injuries, measuring instability through both DV and fluoroscopic methods.
- Results indicate that DV was able to detect incomplete syndesmotic injuries more effectively than fluoroscopy, highlighting its potential as a superior diagnostic tool.
Liquid-liquid phase separation (LLPS) has emerged as a central player in the assembly of membraneless compartments termed biomolecular condensates. These compartments are dynamic structures that can condense or dissolve under specific conditions to regulate molecular functions. Such properties allow biomolecular condensates to rapidly respond to changing endogenous or environmental conditions.
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- Intra-articular screw cut-out is a frequent complication in proximal humerus fractures treated with locking plates, prompting this study to examine technical factors linked to mechanical failures.
- A retrospective analysis of 110 patients from a level 1 trauma center revealed that longer screws, improper lateral translation, inadequate medial support, and varus reduction significantly increased the risk of complications.
- The findings emphasize the need for careful surgical techniques, stressing the importance of reducing screws to less than 45 mm, providing adequate medial support, and maintaining humeral offsets during fixation to improve patient outcomes.