Optimization of the Vacuum Microwave Drying of Tilapia Fillets Using Response Surface Analysis.

This study looked at how vacuum microwave drying (VMD) affects the quality of tilapia fillets ( spp.). It focused on the impact of fillet thickness, microwave power, and vacuum pressure on key quality parameters, such as water activity (Aw), texture, rehydration rate, and whiteness.

A new pyrrolopyrazine alkaloid from the fruit of .

A new pyrrolopyrazine alkaloid, named lycipyrazine A (), alone with seven known alkaloids (-), were isolated from the fruit of The structure of new compound was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their -glucosidase inhibitory activity was screened using acarbose as a positive control. Compound showed strong inhibitory activity against -glucosidase (IC = 3.

Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination.

Toosendanin (TSN) can inhibit the malignant process of many cancers, and has the potential to be developed as an anti-tumor drug. However, the role and mechanism of TSN in prostate cancer (PCa) progression remain unclear. PCa cells (DU145 and LNCaP) were treated with TSN.

Observational Study of Curative Effects Between Complete Video-Assisted Thoracoscopic Surgery and Conservative Treatment for Multiple Rib Fractures in Non-Frail Chests.

Background: Multiple rib fractures (MRFs) are common injuries and result in serious morbidity and mortality after trauma. Complete video-assisted thoracoscopic surgery (c-VATS) has been increasingly used in the treatment of MRFs. This study was to compare the clinical effects of c-VATS and conservative treatment for MRFs.

The METTL3/TGF-β1 signaling axis promotes osteosarcoma progression by inducing MSC differentiation into CAFs via mA modification.

Osteosarcoma, a prevalent and aggressive skeletal malignancy, significantly impacts the prognosis of individuals, particularly young patients. Current treatments, including surgery and chemotherapy, often prove inadequate for advanced osteosarcoma with metastasis. This study investigates the role of the METTL3/TGF-β1 signaling axis in promoting osteosarcoma progression by inducing mesenchymal stem cells (MSCs) to differentiate into cancer-associated fibroblasts (CAFs).