Getah virus triggers ROS-mediated autophagy in mouse Leydig cells.

Introduction: Getah virus (GETV) is a zoonotic virus transmitted via a mosquito-vertebrate cycle. While previous studies have explored the epidemiology and pathogenicity of GETV in various species, its molecular mechanisms remain largely unexplored.

Methods: This study investigated the impact of GETV infection and associated molecular mechanisms on reactive oxygen species (ROS) and autophagy levels in mouse Leydig cells both and .

SSR marker-based genetic diversity and structure analyses of var. from different populations.

Background: var. is a variety in the section of the genus of the family Theaceae which is native to Fangchenggang, Guangxi, China. To date, the genetic diversity and structure of this variety remains to be understood.

circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer.

Pancreatic cancer is among the most challenging tumors to treat, and due to its immune tolerance characteristics, existing immunotherapy methods are not effective in alleviating the disease. Oncolytic virus therapy, a potential new strategy for treating pancreatic cancer, also faces the limitation of being ineffective when used alone. Elucidating the key host endogenous circular RNAs (circRNAs) involved in M1 virus-mediated killing of pancreatic ductal adenocarcinoma (PDAC) cells may help overcome this limitation.

Greenhouse gas emission dynamics and trajectories in urban water supply and wastewater systems.

Urban water utilities are significant energy users and also key actors in decarbonisation. However, the integrated perspective of urban water supply and wastewater system emissions, the relevant driving forces, and the boundaries of inclusions or exclusions, are rarely discussed. This is due to widely disaggregated data, and complex issues regarding the boundary of the system being investigated.

Gualou Guizhi Granule inhibits microglia-mediated neuroinflammation to protect against neuronal apoptosis and .

Object: Neuroinflammation mediated by microglia has emerged as a critical factor in ischemic stroke and neuronal damage. Gualou Guizhi Granule (GLGZG) has been shown to suppress inflammation in lipopolysaccharide (LPS)-activated microglia, though the underlying mechanisms and its protective effects against neuronal apoptosis remain unclear. This study aims to investigate how GLGZG regulates the Notch signaling pathway in microglia to reduce neuroinflammation and protect neurons from apoptosis.