Publications by authors named "G Wongsuvan"

Article Synopsis
  • Melioidosis is a serious infection caused by a bacteria called Burkholderia pseudomallei, often leading to pneumonia or sepsis and high death rates, even with treatment.
  • Researchers studied blood samples from patients with melioidosis and found that it activates certain immune responses differently compared to other infections.
  • They discovered a set of 5 specific genes that can help predict who is more likely to die from melioidosis, which could improve future treatments and patient care.
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Background: The presence of antimicrobial-resistant (AMR) bacteria in edible ice in tropical countries is largely unknown.

Methods: We evaluate the presence of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales in 100 edible ice samples from drink carts in 20 markets in four provinces (five markets/province) in Thailand. Ten samples of commercially sold edible ice in sealed packages were tested as controls.

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In September 2021, a total of 25 patients diagnosed with COVID-19 developed acute melioidosis after (median 7 days) admission to a COVID-19 field hospital in Thailand. Eight nonpotable tap water samples and 6 soil samples were culture-positive for Burkholderia pseudomallei. Genomic analysis suggested contaminated tap water as the likely cause of illness.

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The global burden of sepsis is greatest in low-resource settings. Melioidosis, infection with the gram-negative bacterium , is a frequent cause of fatal sepsis in endemic tropical regions such as Southeast Asia. To investigate whether plasma metabolomics would identify biological pathways specific to melioidosis and yield clinically meaningful biomarkers.

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Rapid diagnostic tests (RDTs) that can facilitate the diagnosis of a panel of tropical infectious diseases are critically needed. DPP® Fever Panel II Asia is a multiplex lateral flow immunoassay comprising antigen and IgM panels for the diagnosis of pathogens that commonly cause febrile illness in Southeast Asia. Accuracy of DPP® Fever Panel II Asia has not been evaluated in clinical studies.

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