Publications by authors named "G Wiese"
Recent studies show the importance of hydrogel geometry for various applications, such as encoding, micromachines, or tissue engineering. However, fabricating hydrogel structures with micrometer-sized features, advanced geometry, and precise control of porosity remains challenging. This work presents hierarchically structured hydrogels, so-called hydrogel patches, with internally deviating regions on a micron-scale.
View Article and Find Full Text PDFFor steric exclusion chromatography (SXC), hydrophilic stationary phases are used to capture the target molecule in the presence of polyethylene glycol. The influence of the structure and pore size of the stationary phase on the process requirements are not yet well understood. To better understand the SXC process, membranes with different pore sizes that served as a stationary phase were compared for the purification of lentiviral vectors (LVs).
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- Magnetic resonance imaging (MRI) is essential for detecting ischemic stroke lesions in mice, but manual segmentation is difficult and inconsistent.
- A new automated segmentation method using deep learning simplifies this process by working directly with raw MRI scans, minimizing preprocessing steps.
- Results show that the automated method achieves higher accuracy in lesion segmentation compared to manual methods, reducing individual bias and standardizing results across research studies.
Objective: To determine serum and urine concentrations of the uremic retention solutes (URSs), indoxyl sulfate (IS), p-cresol sulfate (PCS), and trimethylamine N-oxide (TMAO), and gut microbiota composition in individuals with moderate chronic kidney disease (CKD) compared with matched adults without CKD in a 6-day controlled feeding study.
Design And Methods: This study was a secondary analysis in which 8 adults with moderate CKD were matched for age, sex, and race with 8 adults without CKD in a parallel-arm, 6-day controlled feeding study. IS, PCS, and TMAO were quantified using liquid chromatography-mass spectrometry in fecal samples, fasting serum, and fasting spot urine samples collected at the end of the feeding period.
Background: High-resolution manometry (HRM) is vital in evaluating patients for surgery at the gastroesophageal (GE) junction. Previously, we reported manometry alters surgery choices at the GE junction over 50% of the time, and its components, i.e.
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