Publications by authors named "G Werner"
Background: The parallel wire technique (PW) is a classic part of the antegrade strategy to open chronic total coronary occlusions (CTO).
Aims: With modern wires and dual-lumen catheters (DLC) the approach has evolved, but this progress had not been evaluated in a contemporary registry of CTO interventions.
Method: This analysis is based on 26,589 CTO procedures performed by 36 operators with > 50 procedures annually between 2015 and 2022.
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular growth factors and collateral function as well as on the conditions which may modify their release or function. In 31 patients with total coronary occlusion (TCOs) blood was collected from distal to the occlusion site (collateral circulation) and from the aortic root (systemic circulation). Serum was used to assess its mitogenic potential in [H]-thymidine incorporation assay on human umbilical vein endothelial cells.
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- The CTO-ARC identified the need for standardized definitions in chronic total occlusion (CTO) procedures to avoid bias in attributing complications to different crossing strategies.
- A study analyzed data from 8,673 patients in the European Registry of Chronic Total Occlusions, finding that the antegrade approach was used in 79.2% of cases, while retrograde was used in 20.8%.
- Results showed that alternative antegrade crossing had lower technical success rates and higher complication rates compared to true antegrade and retrograde methods, though it was primarily used as a rescue strategy in most instances.
Background: Tender Coconut Water (TCW) is a nutrient-rich dietary supplement that contains in bioactive secondary metabolites and phytohormones with anti-oxidative and anti-inflammatory properties. Studies on TCW's anti-cancer properties are limited and the mechanism of its anti-cancer effects have not been defined.
Objective: In the present study, we investigate TCW for its anti-cancer properties and, using untargeted metabolomics, we identify components form TCW with potential anti-cancer activity.