Publications by authors named "G Wassink"
The optimal rate of rewarming after therapeutic hypothermia is unclear. Slow rewarming may reduce cardiovascular instability and rebound seizures, but there is little controlled evidence to support this. The present study aimed to determine whether slow rewarming can improve neuroprotection after 72 h of hypothermia.
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- Perinatal hypoxia-ischaemia in extremely preterm infants leads to long-term neurodevelopmental issues, and while insulin-like growth factor-1 (IGF-1) can help with acute brain injuries, its effects on chronic brain damage are not well understood.
- In a study with preterm-equivalent fetal sheep, subjects that underwent asphyxia demonstrated significant brain damage, including loss of white matter and inflammation.
- However, prolonged treatment with IGF-1 after asphyxia improved white matter recovery and reduced inflammation, suggesting it may enhance brain maturation in preterm infants affected by severe asphyxia.
Article Synopsis
- This study investigates the best method for rewarming infants after therapeutic hypothermia to minimize white matter injury following cerebral ischemia.
- Near-term fetal sheep were subjected to either a sham occlusion or cerebral ischemia, then placed in hypothermic conditions for 72 hours, followed by either fast or slow rewarming methods.
- Results showed that the rate of rewarming (fast vs. slow) did not significantly affect white matter protection, indicating that both methods are equally effective after hypothermia in this model.
Brain maturity and many clinical treatments such as therapeutic hypothermia (TH) can significantly influence the morphology of neonatal EEG seizures after hypoxia-ischemia (HI), and so there is a need for generalized automatic seizure identification. This study validates efficacy of advanced deep-learning pattern classifiers based on a convolutional neural network (CNN) for seizure detection after HI in fetal sheep and determines the effects of maturation and brain cooling on their accuracy. The cohorts included HI-normothermia term ( = 7), HI-hypothermia term ( = 14), sham-normothermia term ( = 5), and HI-normothermia preterm ( = 14) groups, with a total of >17,300 h of recordings.
View Article and Find Full Text PDFBackground And Purpose: There is growing evidence that infants with mild hypoxic-ischemic (HI) encephalopathy have increased risk of brain injury and adverse neurodevelopmental outcomes. Currently, there is no approved treatment for these infants. It was previously shown that blocking connexin 43 hemichannels is neuroprotective in models of moderate to severe HI injury.
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