Publications by authors named "G Walzl"
Background: In Tanzania like other developing countries, TB detection is hindered by totally missed, late notification, and delayed diagnosis of active cases. Apart from having TB control strategies and interventions to detect patients and put them on treatment to cut down the chain of transmission, TB remains a health concern. Limited data exist on the burden and trends of tuberculosis in Mwanza, which includes fishing communities and living conditions that are associated with high TB transmission like overcrowding.
View Article and Find Full Text PDFArticle Synopsis
- - The development of the ID93+GLA-SE vaccine aims to reduce tuberculosis (TB) recurrence and tackle drug-resistant strains, with plans for a phase 2b efficacy trial for patients in TB treatment.
- - A study using samples from earlier ID93+GLA-SE trials found changes in blood gene expression post-vaccination, including significant immune response indicators at different time points, influenced by dosage and participant sex.
- - Findings highlight the complex interactions in the immune system when responding to the ID93+GLA-SE vaccine and underline the importance of vaccination timing and dosage on effectiveness.
Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic had a significant impact on tuberculosis (TB) control globally, with the number of new TB diagnoses decreasing. Coinfection with some viruses, especially measles, could aggravate TB in children. This is presumably a result of depressed cellular immunity.
View Article and Find Full Text PDFPurpose: To determine if host urinary biomarker profiles could distinguish between tubercular uveitis (TBU) and other uveitic diseases (OUD) in patients with and without HIV infection.
Methods: Concentrations of 29 different host biomarkers were measured in urine samples using the Luminex platform. Data were analyzed to describe differences between patients diagnosed with and without TBU and with and without HIV co-infection.