Publications by authors named "G W VALENTINE"
Background: Maternal periodontal disease is associated with preterm and low-birthweight deliveries, but randomized trials of likely efficacious treatments (e.g., dental scaling and root planing) during pregnancy have not reduced these adverse outcomes.
View Article and Find Full Text PDFHuman milk (HM) exposure improves short- and long-term outcomes for infants due to a complex milieu of bioactive, stem cell, anti-inflammatory, anti-microbial, and nutritive components. Given this remarkable biologic fluid, non-nutritional utilization of HM as a targeted therapeutic is being explored in pre-clinical and clinical studies. This article describes recent research pertinent to non-nutritional uses of HM for neurologic, gastrointestinal, and infectious pathologies in neonates, as well as future directions.
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- Kidney transplantation greatly improves the quality of life and survival for people with chronic kidney failure, but access is limited in Sub-Saharan Africa, particularly in Tanzania, which established its program five years ago.
- A study at Muhimbili National Hospital analyzed the outcomes of 68 patients who received kidney transplants from live donors between 2017 and 2022, noting that hypertension was the leading cause of chronic kidney disease among recipients.
- The results revealed a high one-year patient survival rate of 91.2% and graft survival rate of 96.7%, although infections were identified as a significant challenge, being the primary cause of death among some recipients.
Early nutritional exposures, including during embryogenesis and the immediate postnatal period, affect offspring outcomes in both the short- and long-term. Alterations of these modifiable exposures shape the developing gut microbiome, intestinal development, and even neurodevelopmental outcomes. A gut-brain axis exists, and it is intricately connected to early life feeding and nutritional exposures.
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