Publications by authors named "G W Milne"
Importance: We recently observed an inverse and time-dependent association between systemic oxidative stress (OxS), measured by urinary biomarkers of nucleic acid oxidation, and colorectal cancer (CRC) risk. Further investigations into other types of OxS markers are warranted.
Objective: To extend the investigation into systemic lipid peroxidation and CRC risk.
Purpose: Randomized controlled trials have failed to validate that neutralizing oxidative stress (OxS) through antioxidant supplementation reduces cancer risk. This study aims to prospectively investigate whether the relationship between systemic OxS and colorectal cancer (CRC) risk changes over the course of cancer development.
Methods: This study utilized a nested case-control design in two Shanghai cohorts for primary analysis and one US cohort for replication analysis.
Consumer product chemicals pose an environmental risk to public health. Exposure during pregnancy to consumer product chemicals, particularly phthalates and phenols, may increase the susceptibility to pregnancy disorders by dysregulating inflammation and oxidative stress. However, existing studies rely on downstream and nonmodifiable markers of these processes.
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- The automated visual inspection (AVI) of liquid-filled vials and syringes in pharmaceutical production uses a spin-stop motion to detach particles for better detection.
- A validated numerical model for a specific glass vial was created to study how different agitation motions and liquid properties affect particle mobilization.
- Findings indicate that higher angular acceleration during agitation improves the wall shear stress distribution, enhancing particle detection, and the developed model can be adapted for various container types and liquids to optimize AVI processes.
Background: Patient and clinician expectations of benefit from recommended management approaches may potentially impact the success of managing musculoskeletal conditions.
Methods: This was a multisite study in an advanced practice musculoskeletal service across Queensland, Australia. Relationships between patient and clinician (advanced physiotherapy practitioner) expectations of benefit, patient characteristics, and clinical outcome recorded 6 months later were explored with regression analysis in 619 patients undergoing non-surgical multidisciplinary care for either knee osteoarthritis (n = 286), low back pain (n = 249) or shoulder impingement syndrome (n = 84).