Publications by authors named "G W MANNING"

The nucleus must maintain stiffness to preserve its shape and integrity to ensure proper function. Defects in nuclear stiffness caused from chromatin and lamin perturbations produce abnormal nuclear shapes common in aging, heart disease, and cancer. Loss of nuclear shape via protrusions called blebs lead to nuclear rupture that is well-established to cause nuclear dysfunction, including DNA damage.

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Article Synopsis
  • A study investigated whether stereotactic body radiotherapy (SBRT) is just as effective as standard radiotherapy for treating localized prostate cancer in terms of treatment failure rates.
  • The trial involved 874 men with early-stage prostate cancer, comparing SBRT (36.25 Gy in 5 sessions) to conventional radiotherapy (78 Gy in 39 sessions or 62 Gy in 20 sessions) over several weeks, focusing on the chance of being free from cancer progression after 5 years.
  • Results showed that SBRT was noninferior to standard treatment, with similar success rates in preventing cancer failure (95.8% for SBRT vs. 94.6% for control) but higher rates of genitour
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Background And Objective: Randomised data on patient-reported outcomes (PROs) for stereotactic body radiotherapy (SBRT) and prostatectomy in localised prostate cancer are lacking. PACE-A compared patient-reported health-related quality of life after SBRT with that after prostatectomy.

Methods: PACE is a phase 3 open-label, randomised controlled trial.

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We use Gürsey's statistical mechanics of a one-dimensional fluid to find a formula for the ratio in the transport of hard spheres across a membrane through a narrow channel that can accommodate molecular movement only in single file. is the membrane permeability for osmotic flow and the permeability for exchange across the membrane in the absence of osmotic flow. The deviation of the ratio from unity indicates the degree of cooperative transport relative to ordinary diffusion of independent molecules.

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