The nucleus must maintain stiffness to preserve its shape and integrity to ensure proper function. Defects in nuclear stiffness caused from chromatin and lamin perturbations produce abnormal nuclear shapes common in aging, heart disease, and cancer. Loss of nuclear shape via protrusions called blebs lead to nuclear rupture that is well-established to cause nuclear dysfunction, including DNA damage.
View Article and Find Full Text PDFBackground And Objective: Randomised data on patient-reported outcomes (PROs) for stereotactic body radiotherapy (SBRT) and prostatectomy in localised prostate cancer are lacking. PACE-A compared patient-reported health-related quality of life after SBRT with that after prostatectomy.
Methods: PACE is a phase 3 open-label, randomised controlled trial.
Eur Phys J E Soft Matter
April 2024
We use Gürsey's statistical mechanics of a one-dimensional fluid to find a formula for the ratio in the transport of hard spheres across a membrane through a narrow channel that can accommodate molecular movement only in single file. is the membrane permeability for osmotic flow and the permeability for exchange across the membrane in the absence of osmotic flow. The deviation of the ratio from unity indicates the degree of cooperative transport relative to ordinary diffusion of independent molecules.
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