[Wilhelm Krücke (1911-1988): on the occasion of the 100th birthday of the great neuropathologist on December 26, 2011].

A short summary is presented on the life, professional development, research work, especially concerning peripheral nervous system, and personality of the former director of the Department of Neuropathology at the Max-Planck-Institute of Brain Research and Edinger Institute of the Johann Wolfgang Goethe-University, both in Frankfurt/Main.

Correlations between ganglioside storage degree and physiological characteristics of neuronal systems--experimental chloroquine intoxication in miniature pig.

Central nervous neuronal patterns of chloroquine-induced ganglioside storage were investigated in miniature pigs. The systematic distribution of this process was first of all characterized by largely identical reproduction of the current storage patterns of native gangliosidosis. Loss of ganglion cells, cytoarchitectonic disintegration and other degenerative changes resulting in the inborn disease were, however, completely avoided by the experimental conditions.

Effect of chloroquine on the activity of some lysosomal enzymes involved in ganglioside degradation.

Chronic chloroquine treatment of miniature pigs resulted in increased activity of several lysosomal enzymes of the liver and brain. The most affected enzyme was alpha-fucosidase which showed a 3-fold increase in liver (P less than 0.001) and a 2-fold increase in the brain (P less than 0.

Lipid accumulation in liver, spleen, lungs and kidneys of miniature-pigs after chloroquine treatment.

Chronic chloroquine treatment of type-Göttingen miniature-pigs induced lipid accumulation in the liver, spleen, lungs and kidneys. The lipid analyses showed marked quantitative and qualitative differences between the organs. In the liver the lipids affected most were cholesteryl esters and glucosylceramides, which were increased at the most 20 times.

Chloroquine intoxication induces ganglioside storage in nervous tissue: a chemical and histopathological study of brain, spinal cord, dorsal root ganglia, and retinal in the miniature pig.

The effect of chronic chloroquine intoxication on lipid composition, particularly the gangliosides, was studied in the nervous system of miniature pigs, type Göttingen. The tissues examined were cerebrum, spinal cord, dorsal root ganglia and retina. Chloroquine was given in the diet in doses of 2.