Publications by authors named "G W Hunter"
Background: About 25% of patients with acute ischemic stroke have lacunar infarct on follow-up imaging. In this secondary analysis from the AcT (Alteplase Compared With Tenecteplase) trial, we assessed if there is variation in safety or efficacy of intravenous thrombolysis by infarct type in patients with no visible occlusion. We also determined if this effect differed between tenecteplase and alteplase.
View Article and Find Full Text PDFLong-term Follow Up of a Complex Case of Foldable Capsular Vitreous Bag Implantation.
Retin Cases Brief Rep
December 2024
Purpose: The Foldable Capsular Vitreous Bag (FCVB) implant is useful in maintaining ocular structure in cases of chronic hypotony secondary to trauma or repeated surgery. There are few published reports of long-term outcomes and no indication of the chronic cellular changes of the adjacent tissues associated with FCVB implantation. We describe one of few FCVB cases in the UK and present histological findings associated with it following secondary enucleation.
View Article and Find Full Text PDFBackground: Clinical trials often struggle to recruit enough participants, with only 10% of eligible patients enrolling. This is concerning for conditions like stroke, where timely decision-making is crucial. Frontline clinicians typically screen patients manually, but this approach can be overwhelming and lead to many eligible patients being overlooked.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma (GBM) is a severe brain cancer that can lead to toxic side effects during treatment, prompting this study to explore genetic and clinical factors associated with vascular toxicities such as thrombosis and hypertension in patients.
- A total of 591 Non-Hispanic White GBM patients were analyzed, with 62 experiencing thrombosis and 59 hypertension, revealing that hypertensive patients had improved survival rates compared to those without hypertension.
- The study found that genetic factors significantly predicted hypertension better than clinical data alone, while corticosteroid use was identified as a notable risk factor for thrombosis, suggesting a need for further research into these associations in cancer treatments.
Article Synopsis
- A study compared the effectiveness of IV tenecteplase and IV alteplase in patients undergoing thrombectomy for acute ischemic stroke, using data from the AcT trial.
- It analyzed the outcomes of different endovascular thrombectomy strategies (stent retriever vs. aspiration) and how they interacted with the type of thrombolysis used.
- Results indicated that while there was no overall difference in efficacy, tenecteplase was associated with better outcomes when paired with aspiration as the first-line strategy.