Hypoxia-Responsive Covalent Organic Framework Nanoplatform for Breast-Cancer-Targeted Cocktail Immunotherapy via Triple Therapeutic Switch Mechanisms.

Covalent organic frameworks (COFs), known for their exceptional in situ encapsulation and precise release capabilities, are emerging as pioneering drug delivery systems. This study introduces a hypoxia-responsive COF designed to encapsulate the chemotherapy drug gambogic acid (GA) in situ. Bimetallic gold-palladium islands were grown on UiO-66-NH (UiO) to form UiO@Au-Pd (UAPi), which were encapsulated with GA through COF membrane formation, resulting in a core-shell structure (UAPiGC).

Mechanical and Energy Evolution Characteristics of Fractured Sandstone Materials: A True Triaxial Experimental Study.

To investigate the mechanical and energy evolution characteristics of fractured rock under true triaxial stresses, true triaxial strength compression experiments on fractured sandstone were conducted with varying crack lengths and widths. The results indicate that under true triaxial stresses, the peak stress of the rock exhibits a gradual decline with an increase in crack length and width. Meanwhile, crack initiation stress and crack damage stress of fractured sandstone also demonstrate a declining trend overall, and the influence of crack length on the characteristic stress (crack initiation stress and crack damage stress) of sandstone is more pronounced than that of crack width.

ATP Citrate Lyase Facilitates Citrate Cleavage in Lemon.

Citric acid is an important organic acid with wide applications and diverse biological functionality. As the predominant organic acid in lemons, citric acid plays a crucial role in determining the flavor of citrus, especially in lemons. ATP citrate lyase (ACL, EC4.

Development of a risk prediction nomogram model of pyrotinib-induced severe diarrhea.

Background: To identify the factors influencing pyrotinib-induced severe diarrhea and to establish a risk prediction nomogram model.

Methods: The clinical data of 226 patients received pyrotinib from two medical institutions from January 2019 to December 2023 were analysed retrospectively. A training set was made up of 167 patients from Hainan Cancer Hospital, and the external validation set was made up of 59 patients from Hainan West Central Hospital.

Self-Cascade of ROS/Glucose-Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF-κB Pathway.

Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, high blood glucose levels, and recalcitrant bacterial infections. This microenvironment is accompanied by long-term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, a hybridized novel gold-palladium (AuPd) nanoshell of the injectable/injectable hydrogel system UiO/AuPd/BNN6/PEG@Gel (UAPsBP@Gel) is developed.