Publications by authors named "G W Hastings"
Article Synopsis
- Ocular wavefront aberrations are crucial for understanding how retinal images are formed and how various factors affect visual functions and development, yet traditional eye models often fail to accurately mimic real eye aberrations due to their simplified structures.
- A study reverse-engineered optical eye models from data collected by multiple laboratories, creating 28 emmetropic and 20 myopic eye models by adjusting 27 anatomical parameters to match measured aberrations.
- Three representative eye models were established, providing insights into typical visual characteristics and serving practical applications such as evaluating dual-focus contact lenses, comparing vision correction methods, and analyzing how objects project across the retina during focusing.
The involvement of the second pair of chlorophylls, termed A and A, in light-induced electron transfer in photosystem I (PSI) is currently debated. Asparagines at PsaA600 and PsaB582 are involved in coordinating the A and A pigments, respectively. Here we have mutated these asparagine residues to methionine in two single mutants and a double mutant in PSI from sp.
View Article and Find Full Text PDFPurpose: The goal was to use SyntEyes modelling to estimate the allowable alignment error of wavefront-guided rigid contact lens corrections for a range of normal and keratoconic eye aberration structures to keep objectively measured visual image quality at or above average levels of well-corrected normal eyes. Secondary purposes included determining the required radial order of correction, whether increased radial order of the corrections further constrained the allowable alignment error and how alignment constraints vary with keratoconus severity.
Methods: Building on previous work, 20 normal SyntEyes and 20 keratoconic SyntEyes were fitted with optimised wavefront-guided rigid contact lens corrections targeting between three and eight radial orders that drove visual image quality, as measured objectively by the visual Strehl ratio, to near 1 (best possible) over a 5-mm pupil for the aligned position.
FTIR spectroscopy accompanied by quantum chemical simulations can reveal important information about molecular structure and intermolecular interactions in the condensed phase. Simulations typically account for the solvent either through cluster quantum mechanical (QM) models, polarizable continuum models (PCM), or hybrid quantum mechanical/molecular mechanical (QM/MM) models. Recently, we studied the effect of aqueous solvent interactions on the vibrational frequencies of lumiflavin, a minimal flavin model, using cluster QM and PCM models.
View Article and Find Full Text PDFTime-resolved step-scan FTIR difference spectroscopy at 77 K has been used to study photosystem I (PSI) from Synechocystis sp. PCC 6803 with four high-potential, 1,4-naphthoquinones (NQs) incorporated into the A binding site. The incorporated quinones are 2-chloro-NQ (2ClNQ), 2-bromo-NQ (2BrNQ), 2,3-dichloro-NQ (ClNQ), and 2,3-dibromo-NQ (BrNQ).
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