Co-culture of Helicobacter pylori with oral microorganisms in human saliva.

Objective: Helicobacter pylori is known for colonizing the gastric mucosa and instigating severe upper gastrointestinal diseases such as gastritis, gastroduodenal ulcers, and gastric cancer. To date, there is no data available on the oral cavity as transmission site, whether H. pylori can survive in the oral cavity or in human saliva.

Multiple "spaces": Using wildlife surveillance, climatic variables, and spatial statistics to identify and map a climatic niche for endemic plague in California, U.S.A.

Regional climatic features in endemic areas can help inform surveillance for plague, a bacterial disease typically transmitted by fleas and maintained in mammals. We use 7,954 coyotes (Canis latrans), a sentinel species for plague, screened for plague exposure by the California Department of Public Health - Vector-Borne Disease Section (CDPH-VBDS; 1983-2015) to identify and map plague-suitable local climates within California to empirically inform ongoing sampling and surveillance plans. Using spatial point processes, we compare the distributions of seropositive and seronegative coyotes within the "space" defined by the first two principal components of PRISM Climate Group 30-year average climate variables (primarily temperature and moisture).

Gram-negative bloodstream infections in six German university hospitals, 2016-2020: clinical and microbiological features.

Purpose: To analyze the longitudinal epidemiology and antimicrobial resistance (AMR) patterns of Gram-negative bloodstream infections (BSI) in Germany.

Methods: Post-hoc analysis of prospectively documented BSI due to Escherichia coli, Klebsiella spp., Enterobacter spp.

Enhancing ascitic fungal infection diagnosis through next-generation sequencing: a pilot study in surgical ICU patients.

Objectives: Ascites, often associated with critical pathologies such as liver cirrhosis or bowel perforation, can be complicated by fungal infection, increasing mortality especially in intensive care settings and demanding rapid diagnosis and adequate treatment. Traditional microbiological diagnostic methods have limited sensitivity in accurately identifying fungal pathogens in ascitic fluid. Alternative diagnostic methods may offer important insights to enable guiding of antifungal therapy and refining empirical treatment strategies.