Aframomumlabdane, a new bislabdane diterpenoid from zingiberaceae).

A previously undescribed bislabdane diterpenoid namely aframomumlabdane (), was isolated from the seed of together with seven known compounds (-). Their structures were established based on a comprehensive analysis of HR-ESI-MS, in conjunction with their 1D and 2D-NMR data. Compound was evaluated for its cytotoxic activity against four cancer cell lines: A549, HepG2, SPC212 and DLD-1.

Chemical profiling by UHPLC-Q-TOF-HRESI-MS/MS and antibacterial properties of (Fabaceae) constituents.

A rapid untargeted UHPLC-Q-TOF-ESI-MS/MS-Based metabolomic profiling of the medicinal plant was performed. A total of 18 metabolites were detected, of which 10 could not be identified. Based on this result, an extensive chemical investigation of the CHCl-MeOH (1:1) extract of this plant was carried out, leading to the isolation of a new ceramide, named entadamide (), together with nine known compounds: monomethyl kolavate (), 24-hydroxytormentic acid () chondrillasterol (), 3---D glucopyranosylstigmasterol (), 3---D glucopyranosylsitosterol (), quercetin 3'-methylether (), 2,3-dihydroxypropyl icosanoate (), 2,3-dihydroxy-propyl 23-hydroxytricosanoate () and 2,3-dihydroxy-propyl 24-hydroxytetracosanoate ().

Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines.

Background: Cancer remains a global health concern and constitutes an important barrier to increasing life expectancy. Malignant cells rapidly develop drug resistance leading to many clinical therapeutic failures. The importance of medicinal plants as an alternative to classical drug discovery to fight cancer is well known.

Soyauxinine, a New Indolopyridoquinazoline Alkaloid from the Stem Bark of Engl. (Rutaceae).

The chemical investigation of the total alkaloid extract (TAE) of the stem bark of (Rutaceae) afforded an unreported indolopyridoquinazoline (compound ) along with nine previously known alkaloids -. In addition, six semi-synthetic derivatives -, , and were prepared by allylation and acetonidation of soyauxinium nitrate (), edulinine (), ribalinine () and arborinine (). The structures and spectroscopic data of five of them are reported herein for the first time.