Publications by authors named "G W Divine"
Background: Early discharge planning is important for safe, cost-effective, and timely hospital discharges. Patients with deconditioning are at risk for prolonged lengths of stay related to discharge needs. Functional mobility outcome measures are associated with discharge disposition.
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- The LAMP trial investigated whether adding pulsed-xenon UV (PX-UV) disinfection to standard cleaning reduces healthcare-associated infections (HAIs), focusing on environmentally implicated HAIs (eiHAIs).
- Conducted in two hospitals, the study included over 25,000 patients and compared the incidence of eiHAIs between the PX-UV group and a control group, finding no significant differences in infection rates.
- Ultimately, the trial concluded that adding PX-UV to terminal cleaning did not effectively reduce eiHAIs, suggesting the need for further research on hospital disinfection methods.
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- Bone biopsies in postmenopausal women with osteoporosis show that those who had atypical femoral fractures (AFF) had been treated with alendronate for a longer period compared to those without AFF.
- The study found that AFF patients had lower bone wall thickness and higher osteoclast surface, indicating possible issues with bone microstructure, but similar bone turnover rates between both groups.
- Atypical femoral fractures in patients using bisphosphonates are more likely to occur after longer treatment durations, highlighting a potential risk factor associated with prolonged antiresorptive therapy.
Background: Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant (XDR) , XDR , and carbapenem-resistant Enterobacterales (CRE) are associated with high mortality rates, and therapeutic options remain limited. This trial assessed whether combination therapy with colistin and meropenem was superior to colistin monotherapy for the treatment of these infections.
Methods: The OVERCOME (Colistin Monotherapy versus Combination Therapy) trial was an international, randomized, double-blind, placebo-controlled trial.
We introduce and validate four adaptive models (AMs) to perform a physiologically based Nested-Model-Selection (NMS) estimation of such microvascular parameters as forward volumetric transfer constant, K, plasma volume fraction, v, and extravascular, extracellular space, v, directly from Dynamic Contrast-Enhanced (DCE) MRI raw information without the need for an Arterial-Input Function (AIF). In sixty-six immune-compromised-RNU rats implanted with human U-251 cancer cells, DCE-MRI studies estimated pharmacokinetic (PK) parameters using a group-averaged radiological AIF and an extended Patlak-based NMS paradigm. One-hundred-ninety features extracted from raw DCE-MRI information were used to construct and validate (nested-cross-validation, NCV) four AMs for estimation of model-based regions and their three PK parameters.
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