Intercomparison of in-well, depth profile and online soil gas measurements for estimating petroleum natural source zone depletion rates: Will in-well gas samples suffice?

Natural Source Zone Deletion (NSZD) is a viable long-term management option for sites impacted by petroleum hydrocarbon fuels. NSZD rate estimation methods for petroleum mass losses often use soil gas gradients of oxygen, carbon dioxide, methane or vapour concentrations through the vadose zone. Seeking greater efficiencies, we investigated if existing short-screened wells are reliable for representative sampling of soil gases in a vadose zone undergoing NSZD.

Identifying silver ore sources for the earliest coins of Athens.

Unlabelled: This study addresses longstanding questions concerning the ore sources used in the first series of coins of ancient Athens known as the (c.540-c.500 BCE) by combining comprehensive numismatic data on 22 coins (16 new and 6 legacy analyses) with lead isotope and surface elemental measurements (MC-ICP-MS and XRF).

Chemical tools to define and manipulate interferon-inducible Ubl protease USP18.

Ubiquitin-specific protease 18 (USP18) is a multifunctional cysteine protease primarily responsible for deconjugating the interferon-inducible ubiquitin-like modifier ISG15 from protein substrates. Here, we report the design and synthesis of activity-based probes (ABPs) that incorporate unnatural amino acids into the C-terminal tail of ISG15, enabling the selective detection of USP18 activity over other ISG15 cross-reactive deubiquitinases (DUBs) such as USP5 and USP14. Combined with a ubiquitin-based DUB ABP, the USP18 ABP is employed in a chemoproteomics screening platform to identify and assess inhibitors of DUBs including USP18.