Publications by authors named "G W Couper"

Prior studies indicate donor age-recipient age (DA-RA) difference may be of prognostic value in adolescents, although not adults. We aim to analyze the relationship between DA-RA difference and long-term survival of young adult heart transplantation (HTx) recipients. First-time, single-organ HTx recipients aged 18-30 who underwent HTx between 2010 and 2020 were analyzed from the United Network for Organ Sharing (UNOS) registry.

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Introduction: Boerhaave syndrome is a rare clinical entity associated with high rates of morbidity and mortality. Early recognition of the symptoms, and identification of the site and extension of the injury are key in improving the prognosis.

Methods: This study presents data on the mortality, morbidity and length of hospital stay in patients diagnosed with Boerhaave syndrome.

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Prior studies reveal adverse effects of transfusion on cardiac surgery, but little is known of transfusion impact on heart transplantation. First-time, single-organ adult heart transplant recipients between January 1, 2010, and December 31, 2020, were included, stratified above or below a model for end-stage liver disease excluding international normalized ratio (MELD-XI) score of 9.4, and propensity score matched to their nearest neighbor.

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Objectives: The HeartMate 3 (Abbott) left ventricular assist device provides substantial improvement in long-term morbidity and mortality in patients with advanced heart failure. The Implantation of the HeartMate 3 in Subjects With Heart Failure Using Surgical Techniques Other Than Full Median Sternotomy study compares thoracotomy-based implantation clinical outcomes with standard median sternotomy.

Methods: We conducted a prospective, multicenter, single-arm study in patients eligible for HeartMate 3 implantation with thoracotomy-based surgical technique (bilateral thoracotomy or partial upper sternotomy with left thoracotomy).

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Article Synopsis
  • Cardiolipin is crucial for mitochondrial function and is impacted by VA-ECMO, which is used in treating acute myocardial infarction, but its effects on heart damage are not well understood.
  • The study found that both human patients requiring VA-ECMO and healthy swine subjected to this treatment showed significantly lower levels of cardiolipin and the enzyme tafazzin, indicating potential detrimental effects on the heart.
  • Importantly, VA-ECMO increased heart damage during ischemia/reperfusion, evidenced by a larger infarct size in swine, suggesting that depleting cardiolipin during treatment may worsen myocardial injury.
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