The NO-donor MPC-1011 stimulates angiogenesis and arteriogenesis and improves hindlimb ischemia via a cGMP-dependent pathway involving VEGF and SDF-1α.

Background And Aims: Peripheral arterial disease (PAD) is an important cause of morbidity and mortality with little effective medical treatment currently available. Nitric oxide (NO) is crucially involved in organ perfusion, tissue protection and angiogenesis.

Methods: We hypothesized that a novel NO-donor, MPC-1011, might elicit vasodilation, angiogenesis and arteriogenesis and in turn improve limb perfusion, in a hindlimb ischemia model.

[Distribution of hand laterality in preschool-age children].

Laterality means functional dominance of one in the pair of organs. It represents the external manifestation of integrative activity of cerebral cortex meaning the domination of functionally dominant hand; the usability lateralization depends on the domination of cerebral hemisphere of gestural lateralization and the domination of cerebral hemisphere or gestural lateralization and the influence of the environment. On the basis of laterality population is divided into right-handed and left-handed with a very stressed degree of lateralization and those undecided with a minimal previal of handidness of one hand.

[Malignant epilepsy in children: therapy with high doses of intravenous immunoglobulin].

22 children with intractable childhood epilepsy (ICE) showing no response to conventional drugs of hormone (ACTH, Synacten) therapy were administered i.v. immunoglobulin (ENDOBULIN immuno) at a dosage of 400 mg/kg on the first and 15th day and subsequently every 3 weeks for 6 months.

[Speech behavior of preschool-age children].

The development of speech is closely related to certain psychic functions. Speech behavior reflects the level of cognitive, emotional and contemplative maturity and the linguistic development of the wider environment in which the child is growing up. The sounds of the language and the configuration of words are directly percepted and reproduced with certain principals of semantics and syntax.

[Psychomotor development in children born with anoxia--perinatal risk factors].

In 1989 a control of psychomotor development was conducted in 318 children born with the Apgar score of 7 and less. The children controlled were of the age of 3 months to 6.5 years old.