Publications by authors named "G Volle"
Objectives: Vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic (VEXAS) syndrome is an adult-onset autoinflammatory disease associated with somatic ubiquitin-like modifier-activating enzyme 1 (UBA1) mutations. We aimed to evaluate the efficacy and safety of targeted therapies.
Methods: Multicentre retrospective study including patients with genetically proven VEXAS syndrome who had received at least one targeted therapy.
Background: The present study aimed to describe the clinical and ultrasound (US) long-term follow-up of patients with transient perivascular inflammation of the carotid artery (TIPIC) syndrome and the risk of recurrence.
Methods: We enrolled patients with a definitive diagnosis of TIPIC syndrome who were included in a retrospective multicenter study. These patients were recontacted at least six months after the first TIPIC episode for a clinical and imaging follow-up.
Article Synopsis
- The spleen plays a key role in filtering blood cells and supporting immune defense, with red pulp clearing damaged red blood cells and white pulp producing antibodies to fight specific infections.
- Acquired impairment of spleen function (hyposplenism) can increase vulnerability to infections, particularly from encapsulated bacteria, as well as raise risks for thrombosis and pulmonary hypertension.
- Sickle cell disease frequently leads to functional asplenia early in life, along with serious complications like hypersplenism and acute splenic sequestration, necessitating a better understanding of spleen function and related pathophysiology.