Publications by authors named "G Verly"
Article Synopsis
- Intracranial aneurysms are rare in children, making up less than 5% of cases, and their unique shape poses challenges for treatment, particularly with the growing use of flow-diverter devices like the Pipeline Embolization Device (PED).
- A systematic review and meta-analysis were conducted using data from Medline, Embase, and Web of Science, focusing on studies with at least three pediatric patients to evaluate outcomes such as occlusion rates, complications, and mortality.
- The analysis included 80 patients and showed a high immediate occlusion rate of 90%, favorable clinical outcomes in 92% of cases, and a low complication rate of 3%, indicating that flow-diverter
Aim: To evaluate the usage and the effectiveness of LVIS Jr device technology in managing wide-neck intracranial aneurysms.
Material And Methods: PubMed, Embase, and Web of Science databases, comprising studies with outcomes related to LVIS Jr use in wide-neck intracranial aneurysms were searched systematically. Data was extracted from the selected articles and subjected to statistical analysis.
Article Synopsis
- WHO Grade 2 meningiomas pose diagnostic and management challenges, with surgery (particularly gross total resection) being essential, often followed by adjuvant radiotherapy, though the effectiveness of this combination is still under investigation.
- A systematic review analyzed data from 23 studies involving 3,822 patients, comparing outcomes of gross total resection alone versus with adjuvant radiotherapy and found that the combination significantly improved progression-free survival, though overall survival needs more research to determine if there's a substantial benefit.
- The study concludes that adjuvant radiotherapy enhances progression-free survival for WHO Grade 2 meningiomas, and future treatments should consider molecular characteristics to improve management strategies.
Introduction: Familial Cerebral Cavernous Malformations (fCCMs) are rare, hereditary conditions characterized by multiple central nervous system lesions. Despite their rarity, CCMs can cause significant clinical challenges when symptomatic, manifesting as seizure and symptomatic hemorrhage (CASH). Guidelines suggest neurosurgical intervention for symptomatic or previously symptomatic lesions, while conservative management is recommended for new-onset epilepsy.
View Article and Find Full Text PDFEarly and long-term outcome of surgical versus conservative management for intracranial cerebral cavernous malformation: Meta-analysis of reconstructed time-to-event data.
Clin Neurol Neurosurg
November 2024
Article Synopsis
- The meta-analysis explores the effectiveness of surgical intervention versus conservative management for symptomatic cerebral cavernous malformations (CCMs), tackling the challenges of uncertain clinical management due to limited trial data.
- Results indicate that while surgical intervention might lead to more events (neurological deficits or bleeding) in the long run, observational management showed a longer mean time before these events occurred.
- The study concludes that observational management could offer better long-term outcomes and emphasizes the necessity for more research, including randomized controlled trials, to improve treatment approaches for CCMs.