Publications by authors named "G Ventriglia"
Congenital hemophilia A (HA) disease severity has traditionally been categorized according to intrinsic factor (F)VIII levels, with <1% of normal indicating severe HA, 1% to 5% moderate HA, and 6% to 40% mild HA. However, mounting evidence illustrates considerable variability in bleeding phenotype regardless of FVIII level. Despite treatment advances, people with moderate or mild HA may be neglected, as treatment guidelines and established norms focus on FVIII levels, and many clinical trials do not include people with FVIII > 1%.
View Article and Find Full Text PDFMusculoskeletal pain (MSP), which impacts bones, muscles, tendons, and ligaments, is a substantial worldwide pain disorder, characterized by muscle soreness, fatigue, inflammation, muscle spasms, sleep disruptions, and functional limitations. MSP is predominantly managed within the primary care setting. Recent consensus recognizes that heat therapy (HT) may provide potential benefits, especially in treating chronic MSP.
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- The lumpfish is being researched for its potential in aquaculture, especially for controlling sea lice in salmon farms, by examining its immune response through Melanomacrophage centers (MMCs) in the liver.
- Liver samples from both hatchery-produced and wild lumpfish were analyzed using various staining techniques to assess MMC density and health indicators, revealing significant lipid accumulation in hatchery males.
- The study found that while hatchery-produced males had more monocytes/macrophages and necrotic areas, MMC density was similar across fish origins and genders, suggesting MMCs may not be effective health markers in lumpfish.
The greater amberjack Seriola dumerili is a promising candidate for aquaculture production. This study compares the ovary transcriptome of greater amberjack sampled in the wild (WILD) with hatchery-produced breeders reared in aquaculture sea cages in the Mediterranean Sea. Among the seven sampled cultured fish, three were classified as reproductively dysfunctional (DysF group), while four showed no signs of reproductive alteration (NormalF group).
View Article and Find Full Text PDFBackground: Emicizumab, a bispecific monoclonal antibody, bridges activated factor (F) IX and FX, mimicking the function of missing or deficient activated FVIII in people with hemophilia A (HA).
Objectives: To evaluate the long-term efficacy and safety of emicizumab prophylaxis in people with HA without FVIII inhibitors in the HAVEN 3 and 4 studies.
Methods: HAVEN 3 and 4 were phase 3 open-label studies.