The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice.

Obesity is a chronic disease that contributes to the development of insulin resistance, type 2 diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) and glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) co-agonism provide an improved therapeutic profile in individuals with T2D and obesity when compared with selective GLP-1R agonism. Although the metabolic benefits of GLP-1R agonism are established, whether GIPR activation impacts weight loss through peripheral mechanisms is yet to be fully defined.

Evaluation of energy recovery, pollutant removal, and microbial dynamics in aged refuse bioreactor for landfill leachate treatment.

The study evaluates the effectiveness of aged refuse bioreactors (ARBs) in treating young landfill leachate and recovering energy through biogas production. Over 90 days, duplicate reactors (ARB1 and ARB2) were operated through three 30-day recirculation cycles under anaerobic conditions, utilizing aged refuse from a closed landfill in Bangalore, India. The study was extended by an additional 900 days without further leachate addition to assess long-term gas generation potential.

Clinical evaluation of AYUSH-SL in patients receiving mass drug administration for the treatment of chronic inflammatory lymphedema, a double blind, placebo controlled, multicentric study.

Background Objectives: A 2.5-year placebo controlled double blind trial was conducted to investigate the safety and efficacy of AYUSH- SL, a poly- herbal Ayurvedic formulation on filarial lymphedema in different endemic areas of India. Lymphatic filariasis (LF) is caused by parasitic nematodes from Wuchereria bancrofti, Brugia malayi, or B.

Evaluation of Posterior Superior Alveolar Canal in Individuals With Cleft Lip and Palate Using Cone Beam Computed Tomography.

Objective: To evaluate the posterior superior alveolar canal (PSAC) in individuals with cleft lip and palate (CLP) by comparing them with individuals with no cleft lip and palate (NC) using cone beam computed tomography (CBCT).

Setting: This is a cross-sectional, analytical study with a prospective sample.

Patients, Participants: CBCT scans of 29 individuals with no cleft and palate (Group I) and 29 individuals with cleft lip and palate (Group II) were used.

An overview of extraction, isolation and characterization techniques of phytocompounds from medicinal plants.

Medicinal plants have been used since time immemorial for the treatment of many types of diseases along with epidemics. They show many biological activities like anti-inflammatory, antioxidant, anti-insecticidal, antibiotic, anti-parasitic, anti-hemolytic properties etc. Different types of bioactive compounds, present in the medicinal plants, play a key role in prevention of diseases and also used for manufacturing medicines.