Publications by authors named "G Van Camp"
Introduction: The transcriptomic characteristics of + non-small cell lung cancer (NSCLC) represent a crucial aspect of its tumor biology. These features provide valuable insights into key dysregulated pathways, potentially leading to the discovery of novel targetable alterations or biomarkers.
Methods: From The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, all available + (n = 10), + (n = 5) and + (n = 5) NSCLC tumor and + cell line (n = 7) RNA-sequencing files were collected.
Article Synopsis
- Pleural mesothelioma (PM) is a rare and aggressive cancer often diagnosed late, highlighting the need for early detection biomarkers through DNA methylation analysis.
- This study generated a large dataset comparing DNA methylation patterns between healthy pleura and PM, identifying over 81,000 differentially methylated sites, including five key sites linked to specific genes.
- The findings indicate that PM has unique methylation profiles that distinguish it from other lung diseases and may aid in understanding the disease’s progression and offer potential for biomarker development.
Introduction: Interval cancer (IC) is an important quality indicator in colorectal cancer (CRC) screening. Previously, we found that fecal immunochemical test (FIT) ICs are more common in women, older age, right-sided tumors, and advanced stage. Here, we extended our existing stage IV patient cohort with clinicopathological and molecular characteristics, to identify factors associated with FIT-IC.
View Article and Find Full Text PDFDNA methylation biomarkers have emerged as promising tools for cancer detection. Common methylation patterns across tumor types allow multi-cancer detection. Droplet digital PCR (ddPCR) has gained considerable attention for methylation detection.
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