Polarization-based idler elimination: enhancing the efficiency of optical parametric amplification.

This study presents a novel way to increase the energy conversion efficiency of optical parametric amplification by eliminating the idler wave from the interaction using consecutive type-I and type-II amplification processes. By using the aforementioned straightforward approach the wavelength tunable narrow-bandwidth amplification with exceptionally high 40% peak pump-to-signal conversion efficiency and 68% peak pump depletion was achieved in the short-pulse regime, while preserving the beam quality factor of less than 1.4.

Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids.

Histone deacetylases (HDACs) play an essential role in the transcriptional regulation of cells through the deacetylation of nuclear histone and non-histone proteins and are promising therapeutic targets for the treatment of various diseases. Here, the synthesis of new compounds in which a hydroxamic acid residue is attached to differently substituted pyrimidine rings via a methylene group bridge of varying length as potential HDAC inhibitors is described. The target compounds were obtained by alkylation of 2-(alkylthio)pyrimidin-4(3)-ones with ethyl 2-bromoethanoate, ethyl 4-bromobutanoate, or methyl 6-bromohexanoate followed by aminolysis of the obtained esters with hydroxylamine.

Numerical study of absorption-enhanced parametric amplification.

Usually the absorption of interacting waves is detrimental to the parametric amplification process. We show that even in the case of large idler wave absorption it is possible to get highly efficient signal amplification as well as amplifier bandwidth enhancement due to back-conversion suppression. We numerically investigated the influence of the idler wave linear losses arising in the case of parametric amplification in 515 nm pumped BBO crystal tuned to signal amplification at 610 nm.

Clustering approach for the analysis of the fluorescent bioaerosol collected by an automatic detector.

Automatically operating particle detection devices generate valuable data, but their use in routine aerobiology needs to be harmonized. The growing network of researchers using automatic pollen detectors has the challenge to develop new data processing systems, best suited for identification of pollen or spore from bioaerosol data obtained near-real-time. It is challenging to recognise all the particles in the atmospheric bioaerosol due to their diversity.

Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia.

Reactive astrogliosis is a response to injury in the central nervous system that plays an essential role in inflammation and tissue repair. It is characterized by hypertrophy of astrocytes, alterations in astrocyte gene expression and astrocyte proliferation. Reactive astrogliosis occurs in multiple neuropathologies, including stroke, traumatic brain injury and Alzheimer's disease, and it has been proposed as a possible source of the changes in diffusion magnetic resonance imaging (dMRI) metrics observed with these diseases.