Publications by authors named "G Valadares de Amorim"
J-domain proteins (JDPs) are essential cochaperones of heat shock protein 70 (Hsp70), as they bind and deliver misfolded polypeptides while also stimulating ATPase activity, thereby mediating the refolding process and assisting Hsp70 in maintaining cellular proteostasis. Despite their importance, detailed structural information about JDP‒Hsp70 complexes is still being explored due to various technical challenges. One major challenge is the lack of more detailed structural data on full-length JDPs.
View Article and Find Full Text PDFObservational databases provide unprecedented opportunities for secondary use in biomedical research. However, these data can be error-prone and must be validated before use. It is usually unrealistic to validate the whole database because of resource constraints.
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- Gut dysbiosis is thought to be connected to immune-mediated diseases like psoriasis, with this study focusing on the gut microbiome in patients with severe psoriatic disease and those with psoriatic arthritis.
- The research utilized 16S rRNA gene sequencing to analyze stool samples from 30 patients, revealing significant differences in the gut microbiome composition, particularly an increase in the Bacteroides genus in those with psoriatic arthritis.
- Although the study highlights these microbiome differences, it notes limitations like the small patient group and ongoing questions about whether gut dysbiosis is a cause or effect of the disease, emphasizing the potential for future interventions.
Rheumatic fever is the most common cause of mitral stenosis worldwide. Embolic events represent severe complications of mitral stenosis. We describe the case of a 45-year-old women who had an ischemic stroke as the initial manifestation of previously unrecognized mitral stenosis in the absence of atrial fibrillation.
View Article and Find Full Text PDFBackground: Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil.
Methods: Participants were followed in Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil.