Publications by authors named "G Vagelli"
Article Synopsis
- The study explores the unclear relationship between glucose levels, brain blood flow, and outcomes in newborns with hypoxic-ischemic encephalopathy during therapeutic hypothermia.
- Researchers used near-infrared spectroscopy (NIRS) to observe regional oxygen saturation in 13 asphyxiated neonates and found no direct correlation between blood glucose and cerebral blood flow.
- However, they noted that increased variability in glucose levels and a trend toward hyperglycemia after 24 hours could help identify neonates at higher risk of brain injury.
Conjugation of known biologically active molecules to carbohydrate frameworks represents a valuable option for the preparation of hybrid, structurally-related families of compounds with the aim of modulating their biological response. Therefore, we present here a study on the preparation of d-, d-, d-, and d- glycoconjugates of an established -hydroxyindole-based (NHI) inhibitor of lactated dehydrogenase (LDH). Structural variations involved the sugar stereochemistry and size as well as the anchoring point of the NHI on the carbohydrate frame (either C-1 or C-6).
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