Publications by authors named "G Vacher"
Age-related Macular Degeneration (AMD) is a multifactorial ocular pathology that destroys the photoreceptors of the macula. Two forms are distinguished, dry and wet AMD, with different pathophysiological mechanisms. Although treatments were shown to be effective in wet AMD, they remain a heavy burden for patients and caregivers, resulting in a lack of patient compliance.
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- Synthetic OligoNucleotides (ON) are emerging as effective therapeutic tools for targeting genetic expression in various diseases, but challenges exist in their controlled release.
- Researchers developed Lipid-OligoNucleotide (LON) conjugates that form stable hydrogels, characterized by unique properties observed through advanced imaging techniques.
- These LON conjugates allow for a longer release of therapeutic sequences after being administered under the skin, offering a new method for sustained delivery of oligonucleotides without the need for additional substances.