[Genetic polymorphism of haptoglobin and quantitative changes in its levels during exposure to asbestos].

The polymorphism and serum levels of haptoglobin were studied in asbestosis patients, in the control and the workers exposed to asbest. Hp1-1 has the highest, Hp2-2--the lowest and Hp2-1 has the intermediate concentration of this protein. In the course of contact with asbest, and especially in asbestosis patients, the haptoglobin levels are higher (for all phenotypes).

[The association of genetic and functional variability of alpha 1-antitrypsin in asbestosis].

The polymorphism and serum levels of alpha 1-antitrypsin (AT) were studied in asbestosis patients, the control and the workers exposed to mineral flax longer or less than ten years. M1S, M3S, M1Z and M2M2 phenotypes had low concentration of this protein. In the course of contact with mineral flax decrease in alpha 1-AT concentration was found.

[Biodemographic parameters as indicators of genetic adaptation to harmful occupational factors (e.g. asbestos)].

A total of 129 women working at asbestos-concentrating factories and asbestos articles manufacture plant, including 87 of them facing asbestosis and 42 exposed to asbestos without asbestosis were examined. There was no marked shifts in the reproductive function and pregnancy results of women facing asbestosis and those exposed to asbestos without asbestosis. Women facing asbestosis has infant mortality higher than other women.

[Gene manifestations in negative man-made environment: a selective genetically determined sensitivity to asbestos].

Genetic polymorphism of the systems of haptoglobin, transferrin, alpha 1-antitrypsin and complement C3 was investigated in patients with asbestosis and in healthy individuals who contacted with asbestos for a long time. The significant differences were discovered between the groups under comparison in the distribution of the phenotypic and genic frequencies in these loci. Simultaneous studies of the levels of these proteins depending on the phenotype demonstrated differentiation of the patients and healthy subjects according to the mean values and dispersions.

[Distribution of ABO, MN, Rh blood groups and Hp, Tr, Gc and C3 serum factors in the Buryat population].

Polymorphism of blood groups ABO, MN, Rh and serum proteins Hp, Tf, Gc, C3 was studied in Buryat populations of Zabaikalie, Pribaikalie, Olkhon island. No indication of significant heterogeneity was observed. Gene frequencies varied in different systems within the ranges: ABO (p-0.