[A non-invasive method of evaluation of Helicobacter pylori urease activity: its perfection and introduction to clinical practice].

The authors have developed a highly sensitive method of non-invasive diagnostics of Helicobacter pylori, the most frequent human infection. Detection of urease activity is based upon measurement of the degree of the elevation of stable 13C isotope content in exhaled air after administration of C-urea as a test reagent. The method has been scarcely applied in Russia because the test preparation, 13C urea had not been produced domestically until 2002.

[Comparative effectiveness of different methods of diagnosis and correction of impaired portal circulation].

The diagnostic effectiveness of X-ray radionuclide and ultrasound determination of portal blood flow and the impact of different treatments on the blood flow were evaluated in 76 patients with hepatic cirrhosis. The treatment regimens were used propranolol (Group 1), isosorbide-5-mononitrate (monosan) (Group 2), and a combined therapy with propranolol in combination with diuretics and a course of intravenous laser irradiation (Group 3). In terms of both clinical and laboratory parameters and the status of portal circulation, the highest effect was observed in the patients receiving the combined therapy.

[Effectiveness of lamivudine in the treatment of chronic HBeAg-negative viral hepatitis B: results of continuous therapy for 18 months].

The efficacy of monotherapy with one of the analogues of synthetic nucleosides (lamivudine) was studied in 22 patients with chronic viral hepatitis B (CVHB). The specific feature of the selected group was that there was no serum HBeAg, which is usually regarded as a sign of viral mutation. The time course of changes in the activity of blood and hepatic inflammatory processes and viral replication were studied at equal intervals.

[The breath test is a necessary step in a physician's practice].

The authors advocate introduction of the respiratory test into clinical practice, show its advantages over other methods of Hp diagnosis and the ability to diagnose non-invasively other gastrointestinal diseases especially in advanced infection primarily in viral hepatitides, HIV infections. The method is safe and comfortable.