Probl Radiac Med Radiobiol
December 2019
Objective: to determine a frequency of germline mutations 185delAG, 5382insC in BRCA1 gene and 6174delT in BRCA2 gene in Ukrainian patients with OC including women who were exposed to the factors of Chornobyl nuclear accident.
Material And Methods: In the study we enrolled 306 OC patients of different age who were tested for the presence of the major BRCA1 and BRCA2 gene mutations using allele specific multiplex polymerase chain reaction.
Results: The mutation frequency in patients exposed to IR with OC (main group) was 5.