[Fas receptor and Fas-ligand expression by cells of primary melanoma, effect on lymphoid infiltration through tumor bed and long-term results of therapy].

Predictive significance of lymphoid infiltration (LI) at the boundary of tumor and intact tissue was evaluated as well as the effect of Fas-receptor (Fas) and Fas-ligand (FasL) melanoma cell expression and lymphoid infiltrate generation, on the one hand, and end results on the other. Samples of melanoma tissues from 283 patients given combined and complex treatment were examined by a single morphologist. Immunohistochemical analysis was done on paraffin-embedded bioptates from 61 patients with marked LI or without it, to assess Fas and FasL expression.

[Adjuvant chemotherapy as a component of complex treatment for skin melanoma].

The efficacy of adjuvant chemotherapy as a component of complex treatment for skin melanoma and that of combined treatment alone was compared. 502 patients were given combined treatment including intensive preoperative irradiation of primary foci (STD-19Gy, TTD-50 Gy, 5 days), their extended excision with or without lymphadenectomy and postoperative irradiation of regional lymph nodes. Combined treatment was administered to 124 patients; additional adjuvant chemotherapy--5-fluorouracil, methotrexate, vincristine and cyclophosphamide (4 components)--200; neo- and adjuvant chemotherapy with cisplatin and doxorubicin (2 components)--106; cisplatin, doxorubicin and dacarbazine (3 components)--29.

[Gender, tumor localization and regional metastases as prognostic factors in combined and complex treatment of cutaneous melanoma].

Data on 373 patients treated for cutaneous melanoma were evaluated to test a hypothesis whether there is a correlation between mechanism of protection from ultraviolet radiation and gender. Cutaneous melanoma of the extremities was identified in 63.2% of females and 26.

[A pH-dependent mechanism of energy transformation in joint fluid cells in osteoarthrosis of the knee joint and benefits of chondroitinsulfate].

Aim: To study bioenergetic processes in the synovial fluid (SF) in osteoarthrosis and to study relevant effects of chondroitinsulphate (structum).

Material And Methods: Changes in bioenergy parameters of SF were analysed in the course of 3-month structum treatment of 15 osteoarthrosis (OA) patients. Classic enzymatic tests and polarographic test of SF cells oxygen absorption rate were used.