[Lipid peroxidation and change in the lipid fraction of plasma in patients with hypertonic disease].

Effect of lipid peroxidation on content and composition of blood plasma lipids was studied in 20 patients with hypertension within various periods after hypertonic crisis. Alterations in blood plasma lipid spectrum were shown to be related to initiation of lipid peroxidation in cell membranes. Dynamics of lipid peroxidation in individual blood plasma lipid fractions appears to reflect the adaptation under conditions of the pathological state of the organism.

[The pulmonary surfactant status in lung immaturity].

Combined study of lungs of 85 foetuses and newborns of various gestational age and 8 newborns dying during the first month of life showed the lung surfactant (LS) system to develop in parallel with formation of respiratory parts and lung capillary network. The level of the LS surface activity increases with the increase of the duration of pregnancy and is determined by the maturation degree of the type II alveolocytes. Changes of the surface activity of the lung extract surface-active fraction in the process of lung maturation correlate with the fractional phospholipid distribution.

[Surface-active properties of pulmonary surfactant and the functional activity of type II alveolocytes at various times of the day under experimental conditions].

Complex examination of lungs in 24 healthy guinea pigs in different periods of day using physicochemical, biochemical and electron-microscopic methods has revealed that the highest surface activity of the pulmonary surfactant (PS) is observed in the evening and at night, as phospholipids contain the highest amount of a surfactant of the phosphatidylcholine fraction the most active in the surface-active respect. An increase in the content of PS phospholipids in this period of the day appears to be a consequence of synthesis and secretion intensification in the second-type alveolocytes, that may be due to an increased effect of the vagus nerve.

[Study of lipid ligands in serum albumin in sportsmen using thin layer chromatography].

Lipid composition and the ability of serum albumin to bind lipid components and products of their peroxidation were investigated in cyclists of different rating during moderate workloads. Ratios of subfractions of phospholipids and other lipid metabolites in blood serum albumin were determined by the method of thin-layer chromatography. Diene conjugates and diene ketones were found to be actively formed in plasma of highly trained cyclists in whom a high lipid capacity of albumin was associated with its low affinity for lipid hydroperoxides.

[Surfactant surface activity and ultrastructural changes in the type-II alveolocytes of fetal and neonatal lungs in experimental inflammation of the maternal lungs].

The lungs of 19 guinea pigs, born from 8 females in which acute and chronic pneumonia had been modelled by transtracheal introduction of sterile fishing-line were investigated. It was established, that in guinea pigs, born in females with acute and chronic pneumonia, the functional immaturity of pneumocytes of the 2-nd type took place. The functional immaturity of pneumocytes of the 2-nd type results in suppression of the surface active characteristics of surfactant.