Hereditary angioedema (HAE) with normal C1-inhibitor level is a rare potentially life-threatening disorder with autosomal dominant inheritance which was first described in 2000. Its clinical presentation is similar to HAE with C1-deficiency. The review is summarized data about its prevalence, mechanisms, genetics and diagnostic criteria.
View Article and Find Full Text PDFThe characteristics of the toxic effect of rose-stained grain of fusarial and non-fusarial nature, as well as the grain experimentally challenged with the toxic strain Fusarium sporotrichiella 53315, were studied basing on the analysis of morphological changes in the internal organs of young rat given orally extracts from the samples studied. The tissue aging processes under the effect of the extract doses producing no irreversible pathologic changes were investigated. It was shown that the extracts of rose-stained natural grain, fusarial and without signs of fusaridiosis, produced similar pathological changes in the morphological structures of the organs in the young rats, the toxicity grew with the increase of the per cent of rose-stained grain.
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